TB500

TB500 is a synthetic version of an active region of thymosin β4. TB500 exhibits anti-fibrotic and wound healing activities by inhibiting the Akt signaling pathway and binding to actin. TB500 is claimed to promote endothelial cell differentiation, angiogenesis in dermal tissues, keratinocyte migration, collagen deposition and decrease inflammation[1][2][3].

Product Specifications

CAS Number

[885340-08-9]

UNSPSC

12352209

Target

Akt; Drug Derivative; P2X Receptor

Type

Peptides

Related Pathways

Membrane Transporter/Ion Channel; Others; PI3K/Akt/mTOR

Applications

Metabolism-protein/nucleotide metabolism

Field of Research

Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/TB500-2.html

Purity

99.81

Solubility

H2O : 250 mg/mL (ultrasonic)

Smiles

O=C(N[C@@H](CCCCN)C(N[C@@H](CCCCN)C(N[C@@H]([C@H](O)C)C(N[C@@H](CCC(O)=O)C(N[C@@H]([C@H](O)C)C(N[C@@H](CCC(N)=O)C(O)=O)=O)=O)=O)=O)=O)[C@H](CC(C)C)NC(C)=O

Molecular Formula

C38H68N10O14

Molecular Weight

889.01

References & Citations

[1]Emmie N M Ho, et al. Doping control analysis of TB-500, a synthetic version of an active region of thymosin β₄, in equine urine and plasma by liquid chromatography-mass spectrometry. J Chromatogr A. 2012 Nov 23;1265:57-69.|[2]Esposito S, et al., Synthesis and characterization of the N-terminal acetylated 17-23 fragment of thymosin beta 4 identified in TB-500, a product suspected to possess doping potential. Drug Test Anal. 2012 Sep;4 (9) :733-8.|[3]Huang CM, et al., In vivo detection of secreted proteins from wounded skin using capillary ultrafiltration probes and mass spectrometric proteomics. Proteomics. 2006 Nov;6 (21) :5805-14.|[4]Shah R, et al., Thymosin β4 inhibits PDGF-BB induced activation, proliferation, and migration of human hepatic stellate cells via its actin-binding domain. Expert Opin Biol Ther. 2018 Jul;18 (sup1) :177-184.