PD 156252

PD 156252 is a hexapeptide that is a highly potent endothelin (ET) antagonist. PD 156252 has enhanced binding affinity for rabbit ETA and rat ETB receptor subtypes with IC50 values of 1.0 and 40 nM, respectively.

Product Specifications

CAS Number

[175592-65-1]

UNSPSC

12352209

Target

Endothelin Receptor

Type

Peptides

Related Pathways

GPCR/G Protein

Applications

Neuroscience-Neuromodulation

Field of Research

Cardiovascular Disease

Assay Protocol

https://www.medchemexpress.com/pd-156252.html

Solubility

10 mM in DMSO

Smiles

OC([C@H](CC1=CNC2=CC=CC=C12)NC([C@H]([C@@H](C)CC)N(C)C([C@H]([C@@H](C)CC)NC([C@H](CC(O)=O)NC([C@H](CC(C)C)NC([C@@H](C3C4=CC=CC=C4CCC5=CC=CC=C53)NC(C)=O)=O)=O)=O)=O)=O)=O

Molecular Formula

C53H69N7O10

Molecular Weight

964.16

References & Citations

[1]Cody WL, et al. Design of a potent combined pseudopeptide endothelin-A/endothelin-B receptor antagonist, Ac-DBhg16-Leu-Asp-Ile-[NMe]Ile-Trp21 (PD 156252) : examination of its pharmacokinetic and spectral properties. J Med Chem. 1997 Jul 4;40 (14) :2228-40.