MK-0812 (Succinate)

MK-0812 Succinate is a potent and selective CCR2 antagonist with high affinity at CCR2.

Product Specifications

CAS Number

[851916-42-2]

UNSPSC

12352005

Hazard Statement

H302, H315, H319

Target

CCR

Type

Reference compound

Related Pathways

GPCR/G Protein; Immunology/Inflammation

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology; Endocrinology

Assay Protocol

https://www.medchemexpress.com/MK-0812-Succinate.html

Purity

99.90

Solubility

DMSO : ≥ 32 mg/mL

Smiles

O=C([C@]1(C(C)C)C[C@H](N[C@H]2CCOC[C@H]2OC)CC1)N3CCC(N=CC(C(F)(F)F)=C4)=C4C3.O=C(O)CCC(O)=O

Molecular Formula

C28H40F3N3O7

Molecular Weight

587.63

Precautions

H302, H315, H319

References & Citations

[1]Min SH, et al. Pharmacological targeting reveals distinct roles for CXCR2/CXCR1 and CCR2 in a mouse model of arthritis.Biochem Biophys Res Commun. 2010 Jan 1;391 (1) :1080-6.|[2]Wisniewski T, et al. Assessment of chemokine receptor function on monocytes in whole blood: In vitro and ex vivo evaluations of a CCR2 antagonist.J Immunol Methods. 2010 Jan 31;352 (1-2) :101-10.