AChE/Aβ-IN-6

BACE1-IN-15 (compound 4j) is a potent inhibitor of BACE1 (β-secretase) that can inhibited the copper ion induced Aβ toxicity, with the EC50 of 0.68 μM[1].

Product Specifications

UNSPSC

12352005

Target

Amyloid-β; Beta-secretase

Type

Reference compound

Related Pathways

Neuronal Signaling

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/ache-aβ-in-6.html

Smiles

O=C(NCC1=CN(CC2=CC=C(C(F)(F)F)C=C2)N=N1)/C=C/C3=CC=CC=C3

Molecular Formula

C20H17F3N4O

Molecular Weight

386.37

References & Citations

[1]Lin-Jie Tan, et al. Discovery of cinnamamide/ester triazole hybrids as potential treatment for Alzheimer’s disease. Bioorganic Chemistry Volume 150, September 2024, 107584.