Human CXCR3 Protein, Flag, His Tag (Detergent)
Chemokines are proteins which induce chemotaxis, promote differentiation of immune cells, and cause tissue extravasation. Given these properties, their role in anti-tumor immune response in the cancer environment is of great interest. Although immunotherapy has shown clinical benefit for some cancer patients, other patients do not respond. One of the mechanisms of resistance to checkpoint inhibitors may be chemokine signaling. The CXCL9, -10, -11/CXCR3 axis regulates immune cell migration, differentiation, and activation, leading to tumor suppression (paracrine axis) . However, there are some reports that show involvements of this axis in tumor growth and metastasis (autocrine axis) . Thus, a better understanding of CXCL9, -10, -11/CXCR3 axis is necessary to develop effective cancer control.
Product Specifications
Background
Specifications
This protein carries a flag tag at the N-terminus and a polyhistidine tag at the C-terminus. The protein has a calculated MW of 43.5 kDa.
Accession Number
P49682-1
Expression Region
Val 2 - Leu 368
Host
HEK293
Target
CXCR3
Conjugation
Unconjugated
Tag
N-Flag & C-6xHis
Source
Human
Stability
The product MUST be stored at -70°C or lower upon receipt; -70°C for 12 months under sterile conditions.
Endotoxin
1.0 EU per μg
Bioactivity
Format
Liquid
Buffer
50 mM HEPES, 150 mM NaCl, DDM, CHS, pH7.5
Additives
Glycerol
Molecular Weight
43.5 kDa
Additionnal Information
Please see 'Shipping-and-Payments' sheet. Website: https://www.acrobiosystems.com/support/shipping-and-payments
Shipping Conditions
Dry ice
Storage Conditions
-70°C
Package Size
100ug*1
Host or Source
HEK293
Species
Human
Protein ID
P49682-1
Preservative
Glycerol
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