FGFR1 inhibitor-11
FGFR1 inhibitor-11 (compound 5g) binds to FGFR1, inactivation of its downstream ERK1/2 and IκBα/NF-κB signaling inhibited RANKL-induced osteoclastogenesis. FGFR1 inhibitor-11 has oral bioactivity[1].
Product Specifications
CAS Number
2157482-40-9
UNSPSC
12352005
Target
FGFR
Type
Reference compound
Related Pathways
Protein Tyrosine Kinase/RTK
Applications
Cancer-Kinase/protease
Field of Research
Metabolic Disease
Assay Protocol
https://www.medchemexpress.com/fgfr1-inhibitor-11.html
Solubility
10 mM in DMSO
Smiles
COC1=CC=C(C=C1)C2=C(C(C3=CC=CC=C3O2)=O)CC4=C(C=CC=C4)O
Molecular Formula
C23H18O4
Molecular Weight
358.39
References & Citations
[1]Zhihao Chen, et al. Discovery of a novel homoisoflavonoid derivative 5g for anti-osteoclastic bone loss via targeting FGFR1. Eur J Med Chem. 2024 Mar 27:270:116335.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
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