Azasetron (hydrochloride)

Azasetron (Y-25130) hydrochloride, a benzamide derivative, is a potent and selective 5-HT3 receptor antagonist. Azasetron is used in the study for Chemotherapy-induced nausea and vomiting (CINV) [1].

Product Specifications

CAS Number

[123040-16-4]

Product Name Alternative

Y-25130 hydrochloride

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

5-HT Receptor

Type

Reference compound

Related Pathways

GPCR/G Protein; Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/Azasetron-hydrochloride.html

Purity

99.76

Solubility

DMSO : 2.22 mg/mL (ultrasonic) |H2O : 20 mg/mL (ultrasonic)

Smiles

O=C(C1=C(OCC(N2C)=O)C2=CC(Cl)=C1)NC3CN4CCC3CC4.[H]Cl

Molecular Formula

C17H21Cl2N3O3

Molecular Weight

386.27

Precautions

H302, H315, H319, H335

References & Citations

[1]Sato, N., et al., Antagonistic activity of Y-25130 on 5-HT3 receptors. Jpn J Pharmacol, 1992. 59 (4) : p. 443-8.|[2]Haga, K., et al., The effects of orally administered Y-25130, a selective serotonin3-receptor antagonist, on chemotherapeutic agent-induced emesis. Jpn J Pharmacol, 1993. 63 (3) : p. 377-83.