Desmorpholinyl Navitoclax-NH-Me

Desmorpholinyl Navitoclax-NH-Me is a Bcl-xL inhibitor. Desmorpholinyl Navitoclax-NH-Me and a CRBN ligand for the E3 ubiquitin ligase can be used in the synthesis of PROTAC BCL-XL degrader XZ739 (HY-133557) [1][2].

Product Specifications

CAS Number

[2365172-82-1]

Product Name Alternative

Desmorpholinyl ABT-263-NH-Me

UNSPSC

12352005

Hazard Statement

H302, H315, H319

Target

Bcl-2 Family; Ligands for Target Protein for PROTAC

Type

Reference compound

Related Pathways

Apoptosis; PROTAC

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/desmorpholinyl-navitoclax-nh-me.html

Concentration

10mM

Purity

98.64

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

O=C(C1=CC=C(N2CCN(CC3=C(C4=CC=C(Cl)C=C4)CCC(C)(C)C3)CC2)C=C1)NS(C5=CC(S(=O)(C(F)(F)F)=O)=C(N[C@@H](CSC6=CC=CC=C6)CCNC)C=C5)(=O)=O

Molecular Formula

C44H51ClF3N5O5S3

Molecular Weight

918.55

Precautions

H302, H315, H319

References & Citations

[1]Guangrong Zheng, et al. Agents de dégradation de protéines bcl-2 pour le traitement du cancer. WO2019144117A1.

Shipping Conditions

Room Temperature

Storage Conditions

-20°C, 3 years; 4°C, 2 years (Powder)

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Available Sizes

Curated Selection

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