DUTP (sodium)

DUTP sodium is the salt form of dUTP. dUTP is a metabolic intermediate in both procaryotes and eucaryotes. dUTP can be used in PCR and RT-PCR to replace dTTP, resulting in the uracil-containing PCR products suitable for most standard applications. dUTP is found to inhibit the enzyme - Cytidine Aminohydrolase from sheep liver[1][2][3][4].

Product Specifications

CAS Number

[94736-09-1]

Product Name Alternative

2'-Deoxyuridine-5'-triphosphate (sodium salt)

UNSPSC

12352005

Target

Biochemical Assay Reagents

Type

Reference compound

Related Pathways

Others

Field of Research

Others

Assay Protocol

https://www.medchemexpress.com/dutp-sodium.html

Solubility

10 mM in DMSO

Smiles

OP(OC[C@@H]1[C@@H](O)C[C@H](N2C(NC(C=C2)=O)=O)O1)(OP(O)(OP(O)(O)=O)=O)=O.[x].[Na]

Molecular Formula

C9H15N2O14P3.xNa

References & Citations

[1]Nayun Kim, et al. dUTP incorporation into genomic DNA is linked to transcription in yeast. Nature. 2009 Jun 25;459 (7250) :1150-3.|[2]Longo, M. C., et al., (1990) . Use of uracil DNA glycosylase to control carry-over contamination in polymerase chain reactions. Gene, 93 (1), 125–128.|[3]Wisdom, G. B., & Orsi, B. A. (1969) . The purification and properties of cytidine aminohydrolase from sheep liver. European journal of biochemistry, 7 (2), 223–230.|[4]Longo, M. C., et al., (1990) . Use of uracil DNA glycosylase to control carry-over contamination in polymerase chain reactions. Gene, 93 (1), 125–128.|[5]Wisdom, G. B., & Orsi, B. A. (1969) . The purification and properties of cytidine aminohydrolase from sheep liver. European journal of biochemistry, 7 (2), 223–230.|[6]Grafstrom, R. H., et al., (1978) . The incorporation of uracil into animal cell DNA in vitro. Cell, 15 (1), 131–140.