GRP75-IN-1 (dihydrochloride)
GRP75-IN-1 hydrochloride (compound 33) is an anti-endometrial cancer (EC) agent that induces apoptosis. GRP75-IN-1 hydrochloride reduces Ca2+ levels in mitochondria by targeting GRP75 and disrupting its interaction with IP3R[1].
Product Specifications
UNSPSC
12352005
Target
Apoptosis
Type
Reference compound
Related Pathways
Apoptosis
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/grp75-in-1-hydrochloride.html
Purity
99.75
Solubility
100 mg/mL (ultrasonic; warming)
Smiles
CN1CCC2(CCN(CC2)CCCCCN3C4=C(SC5=CC=C(C=C53)OC)C=CC=N4)CC1.Cl.Cl
Molecular Formula
C27H40Cl2N4OS
Molecular Weight
539.60
References & Citations
[1]Ling X, et al. Discovery of Novel Azaphenothiazine Derivatives to Suppress Endometrial Cancer by Targeting GRP75 to Impair Its Interaction with IP3R and Mitochondrial Ca2+ Homeostasis. J Med Chem. 2024 Jul 31.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, stored under nitrogen, away from moisture)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Frequently Asked Questions
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