2-Thiouracil-13C,15N2
2-Thiouracil-13C,15N2 is the 13C, 15N labeled 2-Thiouracil. 2-Thiouracil (Thiouracil) is an antithyroid compound. 2-Thiouracil can function as a highly specific melanoma seeker. 2-Thiouracil is a selective inhibitor of neuronal nitric oxide synthase (nNOS) with a Ki of 20 μM.
Product Specifications
Product Name Alternative
Thiouracil-13C,15N2
UNSPSC
12352005
Target
Isotope-Labeled Compounds; NO Synthase
Type
Isotope-Labeled Compounds
Related Pathways
Immunology/Inflammation; Others
Applications
Metabolism-protein/nucleotide metabolism
Field of Research
Endocrinology; Cancer
Assay Protocol
https://www.medchemexpress.com/2-thiouracil-13c-15n2.html
Solubility
10 mM in DMSO
Smiles
O=C(C=C[15NH]1)[15NH][13C]1=S
Molecular Formula
C3 13CH4 15N2OS
Molecular Weight
131.13
References & Citations
[1]Napolitano, A., et al., Mechanism of selective incorporation of the melanoma seeker 2-thiouracil into growing melanin. J Med Chem, 1996. 39 (26) : p. 5192-201.|[2]Palumbo, A., et al. 2-thiouracil is a selective inhibitor of neuronal nitric oxide synthase antagonising tetrahydrobiopterin-dependent enzyme activation and dimerisation. FEBS Lett, 2000. 485 (2-3) : p. 109-12.|[3]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53 (2) :211-216.
Shipping Conditions
Room temperature
Scientific Category
Isotope-Labeled Compounds
Clinical Information
No Development Reported
Available Sizes
Frequently Asked Questions
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