LCRF-0004
LCRF-0004 is a potent inhibitor of RON kinase, with the IC50 value of 10 nM. and a surprising result is also obtained regarding its c-Met inhibitory activity, with the IC50 value of 12 nM. LCRF-0004 plays an important role in cancer research[1].
Product Specifications
CAS Number
1229611-73-7
UNSPSC
12352005
Target
C-Met/HGFR
Type
Reference compound
Related Pathways
Protein Tyrosine Kinase/RTK
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/lcrf-0004.html
Smiles
O=C(NC1=CC=C(C(F)=C1)OC2=C3C(C=C(S3)C4=CN(C=N4)C)=NC=C2)C5=C(N(N=C5)C6=CC=CC=C6)C(F)(F)F
Molecular Formula
C28H18F4N6O2S
Molecular Weight
578.54
References & Citations
[1]Stéphane L Raeppel, et al. Design and synthesis of close analogs of LCRF-0004, a potent and selective RON receptor tyrosine kinase inhibitor. Bioorg Med Chem Lett. 2015 Jun 15;25 (12) :2527-31.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
More Discoveries
Explore Other Products
Browse additional items from our catalog
OKCD03582 96 Well
IFNA Chemi-Luminescent ELISA Kit (Rabbit) (OKCD03582)
Sign In for Pricing
View Details 
K3739703 1.0 µg DNA
Hils1 sgRNA CRISPR Lentivector (Mouse) (Target 2)
Sign In for Pricing
View Details