LCRF-0004
LCRF-0004 is a potent inhibitor of RON kinase, with the IC50 value of 10 nM. and a surprising result is also obtained regarding its c-Met inhibitory activity, with the IC50 value of 12 nM. LCRF-0004 plays an important role in cancer research[1].
Product Specifications
CAS Number
1229611-73-7
UNSPSC
12352005
Target
C-Met/HGFR
Type
Reference compound
Related Pathways
Protein Tyrosine Kinase/RTK
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/lcrf-0004.html
Smiles
O=C(NC1=CC=C(C(F)=C1)OC2=C3C(C=C(S3)C4=CN(C=N4)C)=NC=C2)C5=C(N(N=C5)C6=CC=CC=C6)C(F)(F)F
Molecular Formula
C28H18F4N6O2S
Molecular Weight
578.54
References & Citations
[1]Stéphane L Raeppel, et al. Design and synthesis of close analogs of LCRF-0004, a potent and selective RON receptor tyrosine kinase inhibitor. Bioorg Med Chem Lett. 2015 Jun 15;25 (12) :2527-31.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
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