LP-403812
LP-403812 is a high affinity proline transporter (PROT) inhibitor that produces dose-dependent inhibition of hPROT (IC50=0.11 μM; Ki=0.12 μM) and also inhibits the activity of mouse brain synaptosomal mPROT with the same potency (IC50=0.23 μM) . LP-403812 can be used to study the function of PROT in the brain[1].
Product Specifications
CAS Number
[1142050-84-7]
UNSPSC
12352005
Target
Amino acid Transporter
Type
Reference compound
Related Pathways
Membrane Transporter/Ion Channel
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/lp-403812.html
Smiles
O=C(NC1=NC(N(C(C)(C)C)N=C2C(N3[C@H](CN4CCCC4)CCC3)=O)=C2S1)C5=CC=C(C)C=C5
Molecular Formula
C26H34N6O2S
Molecular Weight
494.65
References & Citations
[1]XuanChuan Yu, et al. "Discovery and characterization of potent small molecule inhibitors of the high affinity proline transporter." Neuroscience letters 451.3 (2009) : 212-216.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Curated Selection
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