LP-403812

LP-403812 is a high affinity proline transporter (PROT) inhibitor that produces dose-dependent inhibition of hPROT (IC50=0.11 μM; Ki=0.12 μM) and also inhibits the activity of mouse brain synaptosomal mPROT with the same potency (IC50=0.23 μM) . LP-403812 can be used to study the function of PROT in the brain[1].

Product Specifications

CAS Number

[1142050-84-7]

UNSPSC

12352005

Target

Amino acid Transporter

Type

Reference compound

Related Pathways

Membrane Transporter/Ion Channel

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/lp-403812.html

Smiles

O=C(NC1=NC(N(C(C)(C)C)N=C2C(N3[C@H](CN4CCCC4)CCC3)=O)=C2S1)C5=CC=C(C)C=C5

Molecular Formula

C26H34N6O2S

Molecular Weight

494.65

References & Citations

[1]XuanChuan Yu, et al. "Discovery and characterization of potent small molecule inhibitors of the high affinity proline transporter." Neuroscience letters 451.3 (2009) : 212-216.