ON1231320

ON1231320 is a highly specific polo like kinase 2 (PLK2) inhibitor with an IC50 of 0.31 μM. ON1231320 blocks tumor cell cycle progression in the G2/M phase in mitosis, causing apoptotic cell death. ON1231320, an arylsulfonyl pyrido-pyrimidinone, has antitumor activity[1][2].

Product Specifications

CAS Number

[1312471-39-8]

UNSPSC

12352005

Target

Apoptosis; Mitosis; Polo-like Kinase (PLK)

Type

Reference compound

Related Pathways

Apoptosis; Cell Cycle/DNA Damage

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/on1231320.html

Purity

99.90

Solubility

DMSO : 50 mg/mL (ultrasonic)

Smiles

O=C1C(S(=O)(C2=CC=C(F)C=C2F)=O)=CC3=CN=C(NC4=CC5=C(NC=C5)C=C4)N=C3N1C

Molecular Formula

C22H15F2N5O3S

Molecular Weight

467.45

References & Citations

[1]M V Ramana Reddy, et al. Discovery of 2- (1H-indol-5-ylamino) -6- (2,4-difluorophenylsulfonyl) -8-methylpyrido[2,3-d]pyrimidin-7 (8H) -one (7ao) as a potent selective inhibitor of Polo like kinase 2 (PLK2) . Bioorg Med Chem. 2016 Feb 15;24 (4) :521-44.|[2]Shashidhar S. Jatiani, et al. Abstract 643: Targeting cancer with a selective ATP-mimetic inhibitor of polo like kinase-2.