OM-153
OM-153 is a potent and orally active tankyrase inhibitor with IC50s of 13 nM and 2 nM for tankyrase 1 and tankyrase 2 (TNKS1/2), respectively. OM-153 inhibits luciferase-based Wnt/β-catenin signaling reporter activity with an IC50 value of 0.63 nM. OM-153 shows inhibition of Wnt/β-catenin signaling and proliferation in COLO 320DM[1][2].
Product Specifications
CAS Number
2406278-81-5
UNSPSC
12352005
Target
PARP; Wnt
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage; Epigenetics; Stem Cell/Wnt
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/om-153.html
Concentration
10mM
Purity
99.30
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
O=C(C1=C2N=CC=NC2=CC=C1)N[C@H]3C[C@H](C4=NN=C(C5=NC=C(OCC)C=C5)[N@]4[C@]6=CC=CC=C6F)C3
Molecular Formula
C28H24FN7O2
Molecular Weight
509.53
References & Citations
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
TNKS1/PARP5A; TNKS2/PARP5B
Available Sizes
Frequently Asked Questions
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