Recombinant Human IL-4 Protein

<strong>Recombinant Human IL-4 Protein</strong>_x000D_ <strong>Catalog number:</strong> B2015610_x000D_ <strong>Lot number:</strong> Batch Dependent_x000D_ <strong>Expiration Date:</strong> Batch dependent_x000D_ <strong>Amount:</strong> 5 µg_x000D_ <strong>Molecular Weight or Concentration:</strong> 14 and 19 kDa, monomer, glycosylated_x000D_ <strong>Supplied as:</strong> Solution_x000D_ <strong>Applications:</strong> a molecular tool for various biochemical applications_x000D_ <strong>Storage:</strong> -20¬∞C_x000D_ <strong>Keywords:</strong> B cell stimulatory factor 1, Binetrakin, BSF 1, BSF1, IL 4, IL4, IL-4, interleukin 4, Pitrakinra_x000D_ <strong>Grade:</strong> Biotechnology grade. All products are highly pure. All solutions are made with Type I ultrapure water (resistivity &gt;18 MŒ©-cm) and are filtered through 0.22 um._x000D_ _x000D_ <strong>References:</strong>_x000D_ 1: Nguyen JK, Austin E, Huang A, Mamalis A, Jagdeo J. The IL-4/IL-13 axis in skin fibrosis and scarring: mechanistic concepts and therapeutic targets Arch Dermatol Res. 2020 Mar;312(2):81-92._x000D_ 2: Conde E, Bertrand R, Balbino B, Bonnefoy J, Stackowicz J, Caillot N, Colaone F, Hamdi S, Houmadi R, Loste A, Kamphuis JBJ, Huetz F, Guilleminault L, Gaudenzio N, Mougel A, Hardy D, Snouwaert JN, Koller BH, Serra V, Bruhns P, Grouard-Vogel G, Reber LL. Dual vaccination against IL-4 and IL-13 protects against chronic allergic asthma in mice Nat Commun. 2021 May 11;12(1):2574._x000D_ 3: Dang B, Gao Q, Zhang L, Zhang J, Cai H, Zhu Y, Zhong Q, Liu J, Niu Y, Mao K, Xiao N, Liu WH, Lin SH, Huang J, Huang SC, Ho PC, Cheng SC. The glycolysis/HIF-1Œ± axis defines the inflammatory role of IL-4-primed macrophages Cell Rep. 2023 May 30;42(5):112471._x000D_ 4: Kummola L, Salomaa T, Ortutay Z, Savan R, Young HA, Junttila IS. IL-4, IL-13 and IFN-Œ≥ -induced genes in highly purified human neutrophils Cytokine. 2023 Apr;164:156159._x000D_ 5: Shi JH, Liu LN, Song DD, Liu WW, Ling C, Wu FX, Wang TT, Liu B, Cui NP, Qin Y, Ni ZY. TRAF3/STAT6 axis regulates macrophage polarization and tumor progression Cell Death Differ. 2023 Aug;30(8):2005-2016._x000D_ 6: Bernstein ZJ, Shenoy A, Chen A, Heller NM, Spangler JB. Engineering the IL-4/IL-13 axis for targeted immune modulation Immunol Rev. 2023 Nov;320(1):29-57._x000D_ 7: Mazloomrezaei M, Hosseini MS, Ahmadi N, Mahmoudi Maymand E, Eftekhar E, Asgari A, Ramezani A. Introducing a New Method for Purification of Human IL-4 by Substitution of a Single Amino Acid in IL-4 Protein Sequence Iran J Immunol. 2022 Dec;19(4):436-445._x000D_ 8: Wang T, Secombes CJ. The evolution of IL-4 and IL-13 and their receptor subunits Cytokine. 2015 Sep;75(1):8-13._x000D_ 9: Zhou T, Yang Z, Ni B, Zhou H, Xu H, Lin X, Li Y, Liu C, Ju R, Ge J, He C, Liu X. IL-4 induces reparative phenotype of RPE cells and protects against retinal neurodegeneration via Nrf2 activation Cell Death Dis. 2022 Dec 20;13(12):1056._x000D_ <a href="https://pubmed.ncbi.nlm.nih.gov/25900776">10: Obmolova G, Teplyakov A, Malia TJ, Keough E, Luo J, Sweet R, Jacobs SA, Yi F, Hippensteel R, O'Neil KT, Gilliland GL. Induced conformational change in human IL-4 upon binding of a signal-neutralizing DARPin Proteins. 2015 Jun;83(6):1191-7. </a>_x000D_ _x000D_ <strong>Products Related to Recombinant Human IL-4 Protein can be found at</strong> <a href="https://moleculardepot.com/product-category/Proteins/"> Proteins</a>