ONCOII
Product Specifications
UNSPSC Description
ONCOII is an Mps1 inhibitor with an IC50 of 10.8 nM. The inhibitory activity of ONCOII against Mps1 is affected by naturally occurring mutations in the Mps1 gene, and cells with Mps1 mutations exhibit increased resistance to ONCOII. ONCOII can be used in cancer research[1].
Target Antigen
Mps1
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage;Cytoskeleton
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/oncoii.html
Smiles
N#CC1=CC=C(NC2=CC(OCC#N)=C(C3=CN(C)N=C3)C=C2)N=C1NC4CCCCC4
Molecular Weight
427.50
References & Citations
[1]Gurden MD, et al. Naturally Occurring Mutations in the MPS1 Gene Predispose Cells to Kinase Inhibitor Drug Resistance. Cancer Res. 2015 Aug 15;75(16):3340-54.
Shipping Conditions
Room temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-164516/ONCOII-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-164516/
Clinical Information
No Development Reported
CAS Number
1263564-94-8
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