Sp-8-Cl-cAMPS
Sp-8-Cl-cAMPS is an analog of cAMP and a derivative of Sp-8-Cl-cAMP. Sp-8-Cl-cAMPS inhibits the growth of human leukemia cell HL-60 and colon cancer cell LS-174T, with IC50 of 8-100 μM. Sp-8-Cl-cAMPS activates the protein kinases cAKI and cAKII, with Ka of 0.25 and 3.2 μM[1].
Product Specifications
CAS Number
142754-28-7
UNSPSC
12352005
Target
PKA
Type
Reference compound
Related Pathways
Stem Cell/Wnt; TGF-beta/Smad
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/sp-8-cl-camps.html
Smiles
S[P@@]1(O[C@H]2[C@@H](O)[C@H](N3C(Cl)=NC4=C3N=CN=C4N)O[C@@H]2CO1)=O
Molecular Formula
C10H11ClN5O5PS
Molecular Weight
379.72
References & Citations
[1]Yokozaki H, et al., Unhydrolyzable analogues of adenosine 3':5'-monophosphate demonstrating growth inhibition and differentiation in human cancer cells. Cancer Res. 1992 May 1;52 (9) :2504-8.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
More Discoveries
Explore Other Products
Browse additional items from our catalog
