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Sp-8-Cl-cAMPS

Sp-8-Cl-cAMPS is an analog of cAMP and a derivative of Sp-8-Cl-cAMP. Sp-8-Cl-cAMPS inhibits the growth of human leukemia cell HL-60 and colon cancer cell LS-174T, with IC50 of 8-100 μM. Sp-8-Cl-cAMPS activates the protein kinases cAKI and cAKII, with Ka of 0.25 and 3.2 μM[1].

Product Specifications

CAS Number

142754-28-7

UNSPSC

12352005

Target

PKA

Type

Reference compound

Related Pathways

Stem Cell/Wnt; TGF-beta/Smad

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/sp-8-cl-camps.html

Smiles

S[P@@]1(O[C@H]2[C@@H](O)[C@H](N3C(Cl)=NC4=C3N=CN=C4N)O[C@@H]2CO1)=O

Molecular Formula

C10H11ClN5O5PS

Molecular Weight

379.72

References & Citations

[1]Yokozaki H, et al., Unhydrolyzable analogues of adenosine 3':5'-monophosphate demonstrating growth inhibition and differentiation in human cancer cells. Cancer Res. 1992 May 1;52 (9) :2504-8.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Frequently Asked Questions

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