NLRP3-IN-51
Product Specifications
UNSPSC Description
NLRP3-IN-51 (Compound 3q) is a potent cholinergic anti-inflammatory pathway (CAP) activators. ANLRP3-IN-51 inhibits Monosodium urate (MSU) (HY-B2130A)-induced IL-1β production in THP-1 cells, indicating its potential against gout arthritis. NLRP3-IN-51 inhibits MSU induced phosphorylation of NF-κB p65, without any inhibitory effect against NLRP3, pro-caspase 1, or the self-cleavage and activation of caspase-1 of the second signaling. Therefore, NLRP3-IN-51 inhibits the initial phase of NLRP3 through CAP activation[1].
Target Antigen
NF-κB
Type
Reference compound
Related Pathways
NF-κB
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/anti-inflammatory-agent-93.html
Smiles
CC1=CC(C)=CC(C)=C1OC2=NC(C[C@H]3[C@](C=C)([H])[C@]4(N(C)C)CC(C)=C3)=C4C=C2
Molecular Weight
388.55
References & Citations
[1]Wu HR, et al. Identification of O-arylated huperzinines as novel cholinergic anti-inflammatory pathway agonists against gout arthritis. Bioorg Chem. 2024 Nov;152:107716.
Shipping Conditions
Room temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-159719/NLRP3-IN-51-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-159719/
Clinical Information
No Development Reported
Curated Selection
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