Verosudil (hydrochloride)

Verosudil (AR-12286) hydrochloride is the hydrochloride form of Verosudil (HY-16758) . Verosudil hydrochloride is a ROCK inhibitor. Verosudil hydrochloride has equal inhibitory activity against ROCK1 and ROCK2 (Ki: 2 nM) . Verosudil hydrochloride is less selective for PKA, PKCT, MRCKA, and CAM2A (Ki: 69 nM, 9322 nM, 28 nM, 5855 nM, respectively) . Verosudil hydrochloride increases trabecular outflow capacity to reduce intraocular pressure. Verosudil hydrochloride is useful in the study of glaucoma and ocular hypertension[1][2].

Product Specifications

CAS Number

[1414854-44-6]

Product Name Alternative

AR-12286 (hydrochloride)

UNSPSC

12352005

Target

ROCK

Type

Reference compound

Related Pathways

Cell Cycle/DNA Damage; Cytoskeleton; Stem Cell/Wnt; TGF-beta/Smad

Applications

Cancer-Kinase/protease

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/verosudil-hydrochloride.html

Smiles

O=C(C(C1=CSC=C1)N(C)C)NC2=CC3=C(C=C2)C(NC=C3)=O.Cl

Molecular Formula

C17H18ClN3O2S

Molecular Weight

363.86

References & Citations

[1]Lin CW, et al. Discovery and Preclinical Development of Netarsudil, a Novel Ocular Hypotensive Agent for the Treatment of Glaucoma. J Ocul Pharmacol Ther. 2018;34 (1-2) :40‐51.|[2]Ren R, et al. Rho Kinase Inhibitor AR-12286 Reverses Steroid-Induced Changes in Intraocular Pressure, Effective Filtration Areas, and Morphology in Mouse Eyes. Invest Ophthalmol Vis Sci. 2023 Feb 1;64 (2) :7.