Foscarnet (trisodium hexahydrate) (Standard)

Foscarnet (trisodium hexahydrate) (Standard) is the analytical standard of Foscarnet (trisodium hexahydrate) . This product is intended for research and analytical applications. Foscarnet trisodium hexahydrate (Trisodium phosphonatoformate hexahydrate) is a viral DNA polymerase activity inhibitor, leading to reversible suppression of viral replication. Foscarnet trisodium hexahydrate is an antiherpesvirus agent used in cytomegalovirus retinitis[1][2][3].

Product Specifications

CAS Number

[34156-56-4]

Product Name Alternative

Trisodium phosphonoformate (hexahydrate) (Standard) ; Phosphonoformic acid trisodium salt (hexahydrate) (Standard)

UNSPSC

12352300

Hazard Statement

H341-H373

Target

DNA/RNA Synthesis; Reference Standards

Type

Reference Standards

Related Pathways

Cell Cycle/DNA Damage; Others

Field of Research

Infection

Assay Protocol

https://www.medchemexpress.com/foscarnet-trisodium-hexahydrate-standard.html

Purity

99.83

Smiles

O=C(P(O[Na])(O[Na])=O)O[Na].[6H2O]

Molecular Formula

CH12Na3O11P

Molecular Weight

300.04

Precautions

P260-P280-P405-P501

References & Citations

[1]Zahn KE, Doublié S, et al. Phosphonoformic acid inhibits viral replication by trapping the closed form of the DNA polymerase. J Biol Chem. 2011 Jul 15;286 (28) :25246-55.|[2]Oberg B, et al. Antiviral effects of phosphonoformate (PFA, foscarnet sodium) .Pharmacol Ther. 1982;19 (3) :387-415.|[3]Hakki M, et al. Moving Past Ganciclovir and Foscarnet: Advances in CMV Therapy.Curr Hematol Malig Rep. 2020 Jan 24.