VMIP-II (1-21) (TFA)

VMIP-II (1-21) (NT21MP) TFA is an inhibitor of CXCR4. vMIP-II (1-21) TFA interacts broadly with CC and CXC chemokine receptors. vMIP-II (1-21) TFA inhibits CXCR4 by competing with 125I-SDF-1R for binding sites (IC50=190 nM) [1].

Product Specifications

Product Name Alternative

NT21MP (TFA) ; V1 peptide (TFA)

UNSPSC

12352209

Target

CXCR

Type

Peptides

Related Pathways

GPCR/G Protein; Immunology/Inflammation

Applications

COVID-19-anti-virus

Field of Research

Cancer; Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/vmip-ii-1-21-tfa.html

Purity

99.92

Solubility

H2O : ≥ 100 mg/mL

Smiles

O=C(NCC(N[C@@H](C)C(N[C@@H](CO)C(N[C@@H](CC1=CNC2=CC=CC=C12)C(N[C@@H](CC3=CNC=N3)C(N[C@@H](CCCNC(N)=N)C(N4[C@@H](CCC4)C(N[C@@H](CC(O)=O)C(N[C@@H](CCCCN)C(N[C@@H](CS)C(N[C@@H](CS)C(N[C@@H](CC(C)C)C(NCC(N[C@@H](CC5=CC=C(C=C5)O)C(N[C@@H](CCC(N)=O)C(N[C@@H](CCCCN)C(N[C@@H](CCCNC(N)=N)C(N6[C@@H](CCC6)C(N[C@@H](CC(C)C)C(N7[C@@H](CCC7)C(O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)[C@H](CC(C)C)N.OC(C(F)(F)F)=O.[x]

Molecular Formula

C108H169N33O27S2.xC2HF3O2

Molecular Weight

2425.84 (free base)

References & Citations

[1]Zhou N, ey al. A novel peptide antagonist of CXCR4 derived from the N-terminus of viral chemokine vMIP-II. Biochemistry. 2000 Apr 4;39 (13) :3782-7.