Propacetamol (Standard)

Propacetamol (Standard) is the analytical standard of Propacetamol (HY-145453) . This product is intended for research and analytical applications. Propacetamol is an orally active prodrug of Acetaminophen (HY-66005), which exerts antipyretic and analgesic effects after metabolism. Propacetamol reduces Aspirin (ASA) (HY-14654) -induced elevation of malondialdehyde (MDA) in gastric mucosa and plasma, regulates the levels of gastric mucosal glutathione (GSH and GSSG) to maintain cellular antioxidant defense, and increases gastric mucosal uric acid (UA) levels. Propacetamol exerts a dose-dependent protective effect against ASA-induced gastric mucosal damage in rats. Propacetamol can be used for the study of gastric mucosal injury by interfering with oxidative stress[1][2][3].

Product Specifications

CAS Number

[66532-85-2]

UNSPSC

12352005

Target

Interleukin Related; Reference Standards

Type

Reference Standards

Related Pathways

Immunology/Inflammation; Others

Field of Research

Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/propacetamol-standard.html

Smiles

O=C(OC1=CC=C(NC(C)=O)C=C1)CN(CC)CC

Molecular Formula

C14H20N2O3

Molecular Weight

264.32

References & Citations

[1]Liou GG, et al. N-Acetyl Cysteine Overdose Inducing Hepatic Steatosis and Systemic Inflammation in Both Propacetamol-Induced Hepatotoxic and Normal Mice. Antioxidants (Basel) . 2021 Mar 12;10 (3) :442.|[2]Zhang Y, et al. Enhanced analgesic effects of propacetamol and tramadol combination in rats and mice. Biol Pharm Bull. 2011;34 (3) :349-53. doi: 10.1248/bpb.34.349|[3]Galunska B, et al. Effects of paracetamol and propacetamol on gastric mucosal damage and gastric lipid peroxidation caused by acetylsalicylic acid (ASA) in rats. Pharmacol Res. 2002 Aug;46 (2) :141-7.