Cucurbitacin IIb (Standard)

Cucurbitacin IIb (Standard) is the analytical standard of Cucurbitacin IIb. This product is intended for research and analytical applications. Cucurbitacin IIb is an active component isolated from Hemsleya amabilis, induces apoptosis with anti-inflammatory activity. Cucurbitacin IIb inhibits phosphorylation of STAT3, JNK and Erk1/2, enhances the phosphorylation of IκB and NF-κB (p65), blocks nuclear translocation of NF-κB (p65) and decreases mRNA levels of IκBα and TNF-α[1].

Product Specifications

CAS Number

[50298-90-3]

UNSPSC

12352211

Target

Apoptosis; Reference Standards

Type

Reference compound

Related Pathways

Apoptosis; Others

Field of Research

Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/cucurbitacin-iib-standard.html

Smiles

C[C@@]([C@@](CC=C1[C@@]2([H])C[C@H](O)[C@@H](O)C1(C)C)([H])[C@@]2(C)C3=O)(C[C@@H](O)[C@]4([H])[C@@](C)(O)C(CCC(C)(O)C)=O)[C@@]4(C3)C

Molecular Formula

C30H48O7

Molecular Weight

520.70

References & Citations

[1]Wang Y, et al. Cucurbitacin IIb exhibits anti-inflammatory activity through modulating multiple cellular behaviors of mouse lymphocytes. PLoS One. 2014 Feb 25;9 (2) :e89751.