BT2 (BCKDC Kinase Inhibitor)

BT2 is an inhibitor of the mitochondrial branched-chain a-ketoacid dehydrogenase complex kinase (BCKDC) - IC50 = 3.19 µM. Inhibition of this kinase has been shown to reduce levels of branched-chain amino acid concentrations in vivo. BT2 also acts as a moderate inhibitor (Ki = 59 µM) of myeloid cell leukemia 1(Mcl 1), a Bcl-2 family protein.