Sesaminol
Sesaminol is an orally active activator for Nrf2-ARE pathway, that promotes the the nuclear translocation of Nrf2 and enhances the NQO1 expression, thereby enhances the cell's defense against oxidative stress. Sesaminol inhibits 6-OHDA -induced ROS production and apoptosis in cell SH-SY5Y. Sesaminol exhibits neuroprotective efficacy against Rotenone (HY-B1756) -induced Parkinson's disease[1].
Product Specifications
CAS Number
74061-79-3
UNSPSC
12352005
Target
Keap1-Nrf2; Quinone Reductase; Reactive Oxygen Species (ROS)
Type
Natural Products
Related Pathways
Immunology/Inflammation; Metabolic Enzyme/Protease; NF-κB
Applications
Neuroscience-Neurodegeneration
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/sesaminol.html
Smiles
OC1=C(C=C2C(OCO2)=C1)[C@@H]3[C@]4([H])[C@@](CO3)([H])[C@@H](C5=CC=C(OCO6)C6=C5)OC4
Molecular Formula
C20H18O7
Molecular Weight
370.35
References & Citations
[1]Kaji H, et al., Sesaminol prevents Parkinson's disease by activating the Nrf2-ARE signaling pathway. Heliyon. 2020 Nov 2;6 (11) :e05342.
Shipping Conditions
Room temperature
Scientific Category
Natural Products
Clinical Information
No Development Reported
Frequently Asked Questions
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