[ (pF) Phe4]Nociceptin (1-13) NH2 (TFA)
[ (pF) Phe4]Nociceptin (1-13) NH2 TFA is a highly potent and selective NOP receptor (OP4) agonist, with a pKi of 10.68 and a pEC50 of 9.31. [ (pF) Phe4]Nociceptin (1-13) NH2 TFA displays high selectivity over δ, κ, and μ opioid receptors (>3000 fold) [1][2].
Product Specifications
UNSPSC
12352209
Target
Opioid Receptor
Type
Peptides
Related Pathways
GPCR/G Protein; Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/pf-phe4-nociceptin-1-13-nh2-tfa.html
Solubility
10 mM in DMSO
Smiles
OC(C(F)(F)F)=O.FC(C=C1)=CC=C1C[C@H](NC(CNC(CNC([C@@H](N)CC2=CC=CC=C2)=O)=O)=O)C(N[C@@H]([C@H](O)C)C(NCC(N[C@@H](C)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CCCCN)C(N[C@@H](CO)C(N[C@@H](C)C(N[C@@H](CCCNC(N)=N)C(N[C@H](C(N)=O)CCCCN)=O)=O)=O)=O)=O)=O)=O)=O)=O
Molecular Formula
C63H100F4N22O17
Molecular Weight
1513.60
References & Citations
[1]Guerrini R, et al. Structure-activity studies of the Phe (4) residue of nociceptin (1-13) -NH (2) : identification of highly potent agonists of the nociceptin/orphanin FQ receptor. J Med Chem. 2001;44 (23) :3956-3964.|[2]Rizzi A, et al. Pharmacological characterisation of [ (pX) Phe4]nociceptin (1-13) NH2 analogues. 2. In vivo studies. Naunyn Schmiedebergs Arch Pharmacol. 2002;365 (6) :450-456.|[3]Bigoni R, et al. Pharmacological characterisation of [ (pX) Phe4]nociceptin (1-13) amide analogues. 1. In vitro studies. Naunyn Schmiedebergs Arch Pharmacol. 2002;365 (6) :442-449.
Shipping Conditions
Room temperature
Scientific Category
Peptides
Clinical Information
No Development Reported
Isoform
NOP Receptor/ORL1
Frequently Asked Questions
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