2-Chloro-ADP (sodium)

2-Chloro-ADP (2-Chloroadenosine 5′-diphosphate) sodium is a Adenosine 5'-diphosphate (ADP; HY-W010918) derivative that induces human platelet aggregation and inhibits stimulated adenylate cyclase[1]. 2-Chloro-ADP sodium inhibits mortalin nucleotide-binding domain (NBD) with a Ki of 45.05 μM[2].

Product Specifications

CAS Number

[82927-78-4]

Product Name Alternative

2-Chloroadenosine 5′-diphosphate (sodium)

UNSPSC

12352005

Target

Adenylate Cyclase; HSP

Type

Reference compound

Related Pathways

Cell Cycle/DNA Damage; GPCR/G Protein; Metabolic Enzyme/Protease

Field of Research

Cardiovascular Disease

Assay Protocol

https://www.medchemexpress.com/2-chloro-adp-sodium.html

Smiles

O[C@H]1[C@@H](O)[C@H](N2C3=NC(Cl)=NC(N)=C3N=C2)O[C@@H]1COP(OP(O[Na])(O[Na])=O)(O[Na])=O

Molecular Formula

C10H11ClN5Na3O10P2

Molecular Weight

527.59

References & Citations

[1]N J Cusack, et al. Competitive inhibition by adenosine 5'-triphosphate of the actions on human platelets of 2-chloroadenosine 5'-diphosphate, 2-azidoadenosine 5'-diphosphate and 2-methylthioadenosine 5'-diphosphate. Br J Pharmacol. 1982 Oct;77 (2) :329-33. |[2]Mitchell A Moseng, et al. 2- and N6-functionalized adenosine-5'-diphosphate analogs for the inhibition of mortalin. FEBS Lett. 2019 Aug;593 (15) :2030-2039.