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Selitrectinib (Standard)

Selitrectinib (Standard) is the analytical standard of Selitrectinib. This product is intended for research and analytical applications. Selitrectinib (LOXO-195) is a next-generation TRK kinase inhibitor, with IC50s of 0.6 nM and TRKA and TRKC, respectively[1].

Product Specifications

CAS Number

[2097002-61-2]

Product Name Alternative

LOXO-195 (Standard)

UNSPSC

12352005

Target

Reference Standards; Trk Receptor

Type

Reference Standards

Related Pathways

Neuronal Signaling; Others; Protein Tyrosine Kinase/RTK

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/selitrectinib-standard.html

Smiles

FC1=CN=C(CC[C@H](N2)C)C([C@](CCC3)([H])N3C(C=CN4N=C5)=NC4=C5C2=O)=C1

Molecular Formula

C20H21FN6O

Molecular Weight

380.42

References & Citations

[1]Drilon A, et al. A Next-Generation TRK Kinase Inhibitor Overcomes Acquired Resistance to Prior TRK Kinase Inhibition in Patients with TRK Fusion-Positive Solid Tumors. Cancer Discov. 2017 Sep;7 (9) :963-972.

Shipping Conditions

Room temperature

Product Datasheet

http://file.medchemexpress.com/batch_PDF/HY-101977R/Selitrectinib-Standard-DataSheet-MedChemExpress.pdf

Product MSDS

http://file.medchemexpress.com/batch_PDF/HY-101977R/

Scientific Category

Reference Standards

Available Sizes

Curated Selection

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