Selisistat
Selisistat (EX-527) is a potent and selective SirT1 (Sir2 in Drosophila melanogaster) inhibitor with an IC50 of 123 nM for SirT1. Selisistat alleviates pathology in multiple animal and cell models of Huntington's disease[1][2].
Product Specifications
CAS Number
49843-98-3
Product Name Alternative
EX-527
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Sirtuin
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage; Epigenetics
Applications
Cancer-programmed cell death
Field of Research
Cancer; Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/EX-527.html
Purity
99.87
Solubility
DMSO : ≥ 100 mg/mL|Ethanol : 10 mg/mL (ultrasonic)
Smiles
O=C(C1C(NC2=C3C=C(Cl)C=C2)=C3CCC1)N
Molecular Formula
C13H13ClN2O
Molecular Weight
248.71
Precautions
H302, H315, H319, H335
References & Citations
[1]Smith MR, et al. A potent and selective Sirtuin 1 inhibitor alleviates pathology in multiple animal and cell models of Huntington's disease. Hum Mol Genet. 2014;23 (11) :2995-3007.|[2]Napper AD, et al. Discovery of indoles as potent and selective inhibitors of the deacetylase SIRT1 [published correction appears in J Med Chem. 2007 Mar 8;50 (5) :1086]. J Med Chem. 2005;48 (25) :8045-8054.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Phase 2
Available Sizes
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