Selisistat

Selisistat (EX-527) is a potent and selective SirT1 (Sir2 in Drosophila melanogaster) inhibitor with an IC50 of 123 nM for SirT1. Selisistat alleviates pathology in multiple animal and cell models of Huntington's disease[1][2].

Product Specifications

CAS Number

[49843-98-3]

Product Name Alternative

EX-527

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Sirtuin

Type

Reference compound

Related Pathways

Cell Cycle/DNA Damage; Epigenetics

Applications

Cancer-programmed cell death

Field of Research

Cancer; Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/EX-527.html

Purity

99.87

Solubility

DMSO : ≥ 100 mg/mL|Ethanol : 10 mg/mL (ultrasonic)

Smiles

O=C(C1C(NC2=C3C=C(Cl)C=C2)=C3CCC1)N

Molecular Formula

C13H13ClN2O

Molecular Weight

248.71

Precautions

H302, H315, H319, H335

References & Citations

[1]Smith MR, et al. A potent and selective Sirtuin 1 inhibitor alleviates pathology in multiple animal and cell models of Huntington's disease. Hum Mol Genet. 2014;23 (11) :2995-3007.|[2]Napper AD, et al. Discovery of indoles as potent and selective inhibitors of the deacetylase SIRT1 [published correction appears in J Med Chem. 2007 Mar 8;50 (5) :1086]. J Med Chem. 2005;48 (25) :8045-8054.