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Pam3CSK4 (TFA)

Pam3CSK4 TFA is a toll-like receptor 1/2 (TLR1/2) agonist with an EC50 of 0.47 ng/mL for human TLR1/2[1].

Product Specifications

CAS Number

[112208-01-2]

Product Name Alternative

Pam3Cys-Ser- (Lys) 4 (TFA)

UNSPSC

12352209

Hazard Statement

H302, H315, H319

Target

Toll-like Receptor (TLR)

Type

Peptides

Related Pathways

Immunology/Inflammation

Applications

COVID-19-immunoregulation

Field of Research

Infection; Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/pam3csk4-tfa.html

Purity

99.89

Solubility

DMSO : 25 mg/mL (ultrasonic) |H2O : 16.67 mg/mL (ultrasonic)

Smiles

OC(C(F)(F)F)=O.CCCCCCCCCCCCCCCC(OCC(OC(CCCCCCCCCCCCCCC)=O)CSC[C@H](NC(CCCCCCCCCCCCCCC)=O)C(N[C@@H](CO)C(N[C@@H](CCCCN)C(N[C@@H](CCCCN)C(N[C@@H](CCCCN)C(N[C@H](C(O)=O)CCCCN)=O)=O)=O)=O)=O)=O.OC(C(F)(F)F)=O.OC(C(F)(F)F)=O

Molecular Formula

C81H156N10O13S.3C2HF3O2

Molecular Weight

1852.30

Precautions

H302, H315, H319

References & Citations

Staphylococcus aureus

Shipping Conditions

Blue Ice

Storage Conditions

-80°C, 2 years; -20°C, 1 year (Powder, sealed storage, away from moisture)

Product Datasheet

http://file.medchemexpress.com/batch_PDF/HY-P1180A/Pam3CSK4-TFA-DataSheet-MedChemExpress.pdf

Product MSDS

http://file.medchemexpress.com/batch_PDF/HY-P1180A/Pam3CSK4-TFA-SDS-MedChemExpress.pdf

Scientific Category

Peptides

Clinical Information

No Development Reported

Isoform

TLR1; TLR2

Citation 01

Chin Herb Med. 2024 Apr 30;16 (3) :422-434.|Int Immunopharmacol. 2022 Dec;113 (Pt A) :109312.|J Pharm Anal. 2025 Jan;15 (1) :101054.|Nat Immunol. 2025 Oct;26 (10) :1660-1672.|Phytomedicine. 2025 Jun:141:156705.|PLoS Pathog. 2024 Nov 5;20 (11) :e1012614.|Sci China Life Sci. 2024 Dec;67 (12) :2664-2677.|Sci Rep. 2022 Oct 12;12 (1) :17058.|Antiviral Res. 2022 Jul:203:105346.|Biochem Biophys Res Commun. 2024 Apr 16:704:149661.|Int Immunopharmacol. 2022 May:106:108613.|Microbes Infect. 2024 Jan-Feb;26 (1-2) :105244.|Mol Immunol. 2021 Feb;130:85-95.|Sci Rep. 2023 Nov 9;13 (1) :19440.

Available Sizes

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