Pam3CSK4 (TFA)
Pam3CSK4 TFA is a toll-like receptor 1/2 (TLR1/2) agonist with an EC50 of 0.47 ng/mL for human TLR1/2[1].
Product Specifications
CAS Number
112208-01-2
Product Name Alternative
Pam3Cys-Ser- (Lys) 4 (TFA)
UNSPSC
12352209
Hazard Statement
H302, H315, H319
Target
Toll-like Receptor (TLR)
Type
Peptides
Related Pathways
Immunology/Inflammation
Applications
COVID-19-immunoregulation
Field of Research
Infection; Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/pam3csk4-tfa.html
Purity
99.89
Solubility
DMSO : 25 mg/mL (ultrasonic) |H2O : 16.67 mg/mL (ultrasonic)
Smiles
OC(C(F)(F)F)=O.CCCCCCCCCCCCCCCC(OCC(OC(CCCCCCCCCCCCCCC)=O)CSC[C@H](NC(CCCCCCCCCCCCCCC)=O)C(N[C@@H](CO)C(N[C@@H](CCCCN)C(N[C@@H](CCCCN)C(N[C@@H](CCCCN)C(N[C@H](C(O)=O)CCCCN)=O)=O)=O)=O)=O)=O.OC(C(F)(F)F)=O.OC(C(F)(F)F)=O
Molecular Formula
C81H156N10O13S.3C2HF3O2
Molecular Weight
1852.30
Precautions
H302, H315, H319
References & Citations
Staphylococcus aureus
Shipping Conditions
Blue Ice
Storage Conditions
-80°C, 2 years; -20°C, 1 year (Powder, sealed storage, away from moisture)
Scientific Category
Peptides
Clinical Information
No Development Reported
Isoform
TLR1; TLR2
Citation 01
Chin Herb Med. 2024 Apr 30;16 (3) :422-434.|Int Immunopharmacol. 2022 Dec;113 (Pt A) :109312.|J Pharm Anal. 2025 Jan;15 (1) :101054.|Nat Immunol. 2025 Oct;26 (10) :1660-1672.|Phytomedicine. 2025 Jun:141:156705.|PLoS Pathog. 2024 Nov 5;20 (11) :e1012614.|Sci China Life Sci. 2024 Dec;67 (12) :2664-2677.|Sci Rep. 2022 Oct 12;12 (1) :17058.|Antiviral Res. 2022 Jul:203:105346.|Biochem Biophys Res Commun. 2024 Apr 16:704:149661.|Int Immunopharmacol. 2022 May:106:108613.|Microbes Infect. 2024 Jan-Feb;26 (1-2) :105244.|Mol Immunol. 2021 Feb;130:85-95.|Sci Rep. 2023 Nov 9;13 (1) :19440.
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