Swainsonine
Swainsonine (Tridolgosir) is an natural indolizidine alkaloid, a potent and reversible α-mannosidase inhibitor. Swainsonine induces apoptosis and cell cycle arrest at G2/M phase. Swainsonine shows anti-tumor activity[1][2][3].
Product Specifications
CAS Number
72741-87-8
Product Name Alternative
Tridolgosir
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Antibiotic; Apoptosis
Type
Natural Products
Related Pathways
Anti-infection; Apoptosis
Applications
Cancer-programmed cell death
Field of Research
Cancer; Infection
Assay Protocol
https://www.medchemexpress.com/swainsonine.html
Purity
99.9
Solubility
H2O : 4.17 mg/mL (ultrasonic)
Smiles
O[C@@H]1[C@H](O)CN2CCC[C@@H](O)[C@]12[H]
Molecular Formula
C8H15NO3
Molecular Weight
173.21
Precautions
H302, H315, H319, H335
References & Citations
[1]Dorling PR, et al. Inhibition of lysosomal alpha-mannosidase by swainsonine, an indolizidine alkaloid isolated from Swainsona canescens. Biochem J. 1980 Nov 1;191 (2) :649-51.|[2]Sun L, et al. Swainsonine represses glioma cell proliferation, migration and invasion by reduction of miR-92a expression. BMC Cancer. 2019 Mar 19;19 (1) :247. doi: 10.1186/s12885-019-5425-7.|[3]Santos FM, et al. Increased antitumor efficacy by the combined administration of swainsonine and cisplatin in vivo. Phytomedicine. 2011 Sep 15;18 (12) :1096-101.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C, 3 years (Powder)
Scientific Category
Natural Products
Clinical Information
Phase 2
Available Sizes
Frequently Asked Questions
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