Cortistatin-8

Cortistatin-8 (CST-8; PCFWKTCK), a neuropeptide, is a GHS-R1a antagonist by counteracting the response of ghrelin on gastric acid secretion. Cortistatin-8 can modulate GH release from somatotroph cells. Cortistatin-8 is a synthetic CST-analogue devoid of any binding affinity to SST-R but capable to bind the GHS-R1a. Cortistatin-8 can exert antagonistic effects on ghrelin actions either in vitro or in vivo in animals[1].

Product Specifications

CAS Number

[485803-62-1]

Product Name Alternative

PCFWKTCK

UNSPSC

12352209

Target

GHSR

Type

Reference compound

Related Pathways

GPCR/G Protein

Applications

Metabolism-protein/nucleotide metabolism

Field of Research

Metabolic Disease

Assay Protocol

https://www.medchemexpress.com/cortistatin-8.html

Purity

98.86

Smiles

O=C(N[C@@H]1CC2=CNC3=CC=CC=C23)[C@H](CC4=CC=CC=C4)NC([C@@]([H])(NC([C@@H]5CCCN5)=O)CSSC[C@H](NC([C@@]([H])(NC([C@@]([H])(NC1=O)CCCCN)=O)[C@@H](C)O)=O)C(N[C@@H](CCCCN)C(N)=O)=O)=O

Molecular Formula

C47H68N12O9S2

Molecular Weight

1009.25

References & Citations

[1]F Prodam, et al. Cortistatin-8, a synthetic cortistatin-derived ghrelin receptor ligand, does not modify the endocrine responses to acylated ghrelin or hexarelin in humans. Neuropeptides. 2008 Feb;42 (1) :89-93.