2-Hydroxyisoquinoline-1,3 (2H,4H) -dione

Hydroxyisoquinoline-1,3 (2H,4H) -dione (compound 6a) is a HIV-1 integrase (IN) and HIV-1 reverse transcriptase (RT) ribonuclease H (RNase H) inhibitor with an IC50 value of 6.32, 5.9 µM, respectively[1].

Product Specifications

CAS Number

[6890-08-0]

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

HIV Integrase

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease

Field of Research

Infection

Assay Protocol

https://www.medchemexpress.com/2-hydroxyisoquinoline-1-3-2h-4h-dione.html

Purity

98.0

Smiles

C1=CC=C2C(=C1)CC(=O)N(C2=O)O

Molecular Formula

C9H7NO3

Molecular Weight

177.16

Precautions

H302, H315, H319, H335

References & Citations

[1]Billamboz M, et al. Design, synthesis, and biological evaluation of a series of 2-hydroxyisoquinoline-1,3 (2H,4H) -diones as dual inhibitors of human immunodeficiency virus type 1 integrase and the reverse transcriptase RNase H domain. J Med Chem. 2008 Dec 25;51 (24) :7717-30.