Antagonist G (TFA)
Antagonist G TFA is a potent vasopressin antagonist. Antagonist G is also a weak antagonist of GRP and Bradykinin. Antagonist G induces AP-1 transcription and sensitizes cells to chemotherapy[1][2].
Product Specifications
UNSPSC
12352209
Target
Apoptosis; Vasopressin Receptor
Type
Peptides
Related Pathways
Apoptosis; GPCR/G Protein
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/antagonist-g-tfa.html
Solubility
H2O
Smiles
CSCC[C@@H](C(N)=O)NC([C@H](CC(C)C)NC([C@@H](CC1=CNC2=C1C=CC=C2)NC([C@H](CC3=CC=CC=C3)N(C([C@@H](CC4=CNC5=C4C=CC=C5)NC([C@H](CCCNC(N)=N)N)=O)=O)C)=O)=O)=O.OC(C(F)(F)F)=O
Molecular Formula
C51H67F3N12O8S
Molecular Weight
1065.21
References & Citations
[1]P J Woll, et al. A neuropeptide antagonist that inhibits the growth of small cell lung cancer in vitro. Cancer Res. 1990 Jul 1;50 (13) :3968-73.|[2]A C MacKinnon, et al. [Arg6, D-Trp7,9, NmePhe8]-substance P (6–11) (antagonist G) inducesP-1 transcription and sensitizes cells to chemotherapy. Br J Cancer. 2000 Oct; 83 (7) : 941–948.
Shipping Conditions
Room temperature
Scientific Category
Peptides
Clinical Information
No Development Reported
Frequently Asked Questions
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