Daphnegiravone D
Product Specifications
UNSPSC Description
Daphnegiravone D (compound 70) is an HDAC6 inhibitor with anti-hepatocellular carcinoma activity. Daphnegiravone D can induce apoptosis and selectively inhibit the proliferation of liver cancer cells through the p38 and JNK MAPK pathways[1].
Target Antigen
Apoptosis; HDAC; p38 MAPK
Type
Natural Products
Related Pathways
Apoptosis;Cell Cycle/DNA Damage;Epigenetics;MAPK/ERK Pathway
Applications
Cancer-Kinase/protease
Field of Research
CANCER
Assay Protocol
https://www.medchemexpress.com/daphnegiravone-d.html
Smiles
O=C1C(OC)=C(C2=CC(C/C=C(C)\C)=C(O)C=C2)OC3=C(C/C=C(C)\C)C(O)=CC(O)=C31
Molecular Weight
436.50
References & Citations
[1]Wang D, et al. A new Prenylated Flavonoid induces G0/G1 arrest and apoptosis through p38/JNK MAPK pathways in Human Hepatocellular Carcinoma cells. Sci Rep. 2017 Jul 18;7(1):5736.|[2]Chen JJ, et al. Network pharmacology predicted HDAC6 as a potential target of flavones from Daphne giraldii on hepatocellular carcinoma. Nat Prod Res. 2021 Sep;35(18):3171-3175.
Shipping Conditions
Room temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-N13121/Daphnegiravone-D-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-N13121/
Clinical Information
No Development Reported
CAS Number
2581826-37-9
Curated Selection
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