Daphnegiravone D
Daphnegiravone D (compound 70) is an HDAC6 inhibitor with anti-hepatocellular carcinoma activity. Daphnegiravone D can induce apoptosis and selectively inhibit the proliferation of liver cancer cells through the p38 and JNK MAPK pathways[1].
Product Specifications
CAS Number
2581826-37-9
UNSPSC
12352005
Target
Apoptosis; HDAC; p38 MAPK
Type
Natural Products
Related Pathways
Apoptosis; Cell Cycle/DNA Damage; Epigenetics; MAPK/ERK Pathway
Applications
Cancer-Kinase/protease
Field of Research
CANCER
Assay Protocol
https://www.medchemexpress.com/daphnegiravone-d.html
Smiles
O=C1C(OC)=C(C2=CC(C/C=C(C)\C)=C(O)C=C2)OC3=C(C/C=C(C)\C)C(O)=CC(O)=C31
Molecular Formula
C26H28O6
Molecular Weight
436.50
References & Citations
[1]Wang D, et al. A new Prenylated Flavonoid induces G0/G1 arrest and apoptosis through p38/JNK MAPK pathways in Human Hepatocellular Carcinoma cells. Sci Rep. 2017 Jul 18;7 (1) :5736.|[2]Chen JJ, et al. Network pharmacology predicted HDAC6 as a potential target of flavones from Daphne giraldii on hepatocellular carcinoma. Nat Prod Res. 2021 Sep;35 (18) :3171-3175.
Shipping Conditions
Room temperature
Scientific Category
Natural Products
Clinical Information
No Development Reported
Frequently Asked Questions
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