Norzopiclone

Norzopiclone is the inactive metabolite of Zopiclone. Norzopiclone has some anxiolytic properties.

Product Specifications

CAS Number

[59878-63-6]

Product Name Alternative

N-Desmethyl zopiclone; RP 32273

UNSPSC

12352005

Hazard Statement

H225-H302+H332-H319

Target

Drug Metabolite

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/Norzopiclone.html

Solubility

10 mM in DMSO

Smiles

O=C(N1CCNCC1)OC2N(C3=NC=C(Cl)C=C3)C(C4=NC=CN=C42)=O

Molecular Formula

C16H15ClN6O3

Molecular Weight

374.78

Precautions

P210-P233-P240-P241-P242-P243-P261-P264-P270-P271-P280-P303+P361+P353-P304+P340-P305+P351+P338-P330-P370+P378-P403+P235-P501

References & Citations

[1]Sha Y, et al. Synthesis of RP 48497, an impurity of eszopiclone. Molecules. 2008 Aug 22;13 (8) :1817-21.|[2]Thomas P. Jerussi, et al. Methods of making and using N-desmethylzopiclone. US 6339086 B1.|[3]Tornio A, et al. The CYP2C8 inhibitor gemfibrozil does not increase the plasma concentrations of zopiclone. Eur J Clin Pharmacol. 2006 Aug;62 (8) :645-51.