Dp44mT

Dp44mT is an iron chelator with selective anticancer activity.

Product Specifications

CAS Number

[152095-12-0]

UNSPSC

12352005

Hazard Statement

H301

Target

Apoptosis; Ferroptosis

Type

Reference compound

Related Pathways

Apoptosis

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/Dp44mT.html

Purity

98.0

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

S=C(N/N=C(C1=NC=CC=C1)\C2=NC=CC=C2)N(C)C

Molecular Formula

C14H15N5S

Molecular Weight

285.37

Precautions

H301

References & Citations

[1]Rao VA, et al. The iron chelator Dp44mT causes DNA damage and selective inhibition of topoisomerase IIalpha in breast cancer cells. Cancer Res. 2009 Feb 1;69 (3) :948-57.|[2]Lovejoy DB, et al. Antitumor activity of metal-chelating compound Dp44mT is mediated by formation of a redox-active copper complex that accumulates in lysosomes. Cancer Res. 2011 Sep 1;71 (17) :5871-80.