Butacaine

Butacaine is a reversible nerve conduction blocker. Butacaine acts on the nervous system and nerve fibers, can cause both sensory and motor paralysis. Butacaine inhibits the NavBh currents. Butacaine can form inclusion complexes with α-cyclodextrin (α-CD) and β-cyclodextrin (β-CD) . Butacaine is commonly used as a negative control for other local anesthetics[1][2][3].

Product Specifications

CAS Number

[149-16-6]

UNSPSC

12352005

Hazard Statement

H301

Target

Sodium Channel

Type

Reference compound

Related Pathways

Membrane Transporter/Ion Channel

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/Butacaine.html

Purity

99.84

Solubility

DMSO : 100 mg/mL (ultrasonic; warming; heat to 60°C)

Smiles

CCCCN(CCCOC(C1=CC=C(N)C=C1)=O)CCCC

Molecular Formula

C18H30N2O2

Molecular Weight

306.44

Precautions

H301

References & Citations

[1]Hashemianzadeh S M, et al. Quantum chemical study of the host-guest inclusion complexes of the local anaesthetic drugs, procaine hydrochloride and butacaine hydrochloride, with α-and β-cyclodextrins[J]. Monatshefte für Chemie-Chemical Monthly, 2008, 139 (7) : 763-771. |[2]Miller ZA, et al. Lidocaine induces apoptosis in head and neck squamous cell carcinoma through activation of bitter taste receptor T2R14. Cell Rep. 2023 Dec 26;42 (12) :113437. |[3]Fan X, et al. Local anesthetics impair the growth and self-renewal of glioblastoma stem cells by inhibiting ZDHHC15-mediated GP130 palmitoylation. Stem Cell Res Ther. 2021 Feb 4;12 (1) :107.