YT-8-8

YT-8-8 is a ligand of p62-ZZ domain. YT-8-8 can activate p62-dependent selective macroautophagy. YT-8-8 can be used for AUTOTAC design[1].

Product Specifications

CAS Number

[892572-23-5]

UNSPSC

12352005

Target

P62

Type

Reference compound

Related Pathways

Autophagy

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/yt-8-8.html

Purity

98.57

Solubility

DMSO : 116.67 mg/mL (ultrasonic)

Smiles

OCCNCCNCC1=CC(OCC2=CC=C(F)C=C2)=CC=C1

Molecular Formula

C18H23FN2O2

Molecular Weight

318.39

References & Citations

[1]Ji CH, et al. The AUTOTAC chemical biology platform for targeted protein degradation via the autophagy-lysosome system. Nat Commun. 2022 Feb 16;13 (1) :904.

Shipping Conditions

Room Temperature

Storage Conditions

4°C (Powder, stored under nitrogen, away from moisture)

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Available Sizes

Curated Selection

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