YT-8-8
YT-8-8 is a ligand of p62-ZZ domain. YT-8-8 can activate p62-dependent selective macroautophagy. YT-8-8 can be used for AUTOTAC design[1].
Product Specifications
CAS Number
[892572-23-5]
UNSPSC
12352005
Target
P62
Type
Reference compound
Related Pathways
Autophagy
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/yt-8-8.html
Purity
98.57
Solubility
DMSO : 116.67 mg/mL (ultrasonic)
Smiles
OCCNCCNCC1=CC(OCC2=CC=C(F)C=C2)=CC=C1
Molecular Formula
C18H23FN2O2
Molecular Weight
318.39
References & Citations
[1]Ji CH, et al. The AUTOTAC chemical biology platform for targeted protein degradation via the autophagy-lysosome system. Nat Commun. 2022 Feb 16;13 (1) :904.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, stored under nitrogen, away from moisture)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Curated Selection
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