Fluorescent Human Claudin-18.2 Full Length Protein (VLP)
Fluorescent Human Claudin-18.2 Full Length Protein-VLP (CL2-HF218) is expressed from human 293 cells (HEK293) . It contains AA Met 1 - Val 261 (Accession # P56856-2) .
Product Specifications
Background
Claudins (CLDNs) are a family of proteins that form tight junctions and maintain the polarity of epithelial and endothelial cells. CLDN18 is specifically expressed in the stomach and lung. Of the two CLDN18 isoform transcripts produced by alternative splicing, CLDN18.2 is a highly selective gastric lineage marker that determines the gastric phenotype in a neoplastic condition, whereas CLDN18.1 is lung specific. CLDN18.2 is a highly selective gastric lineage antigen expressed exclusively on short-lived differentiated gastric epithelial cells where it has only limited accessibility to antibody drugs.14,15 CLDN18.2 is maintained during the course of malignant transformation and thus frequently displayed on the surface of human gastric cancer cells.
Specifications
This protein carries a GFP tag.
Accession Number
P56856-2
Expression Region
Met 1 - Val 261
Host
HEK293
Target
Claudin-18.2
Conjugation
GFP Fusion
Tag
GFP Tag
Source
Human
Stability
● The product MUST be stored at -70°C or lower upon receipt; ● -70°C for 12 months under sterile conditions.
Endotoxin
1.0 EU per μg
Bioactivity
Immobilized Fluorescent Human Claudin-18.2 Full Length Protein-VLP (HEK293) (Cat. No. CL2-HF218) at 5 μg/mL (100 μL/well) can bind Monoclonal Anti-Chimeric Claudin-18.2 Antibody, Human IgG1 with a linear range of 0.1-3 ng/mL (QC tested).
Format
Liquid
Buffer
PBS, pH7.4
Additives
Trehalose
Shipping Conditions
Dry ice
Storage Conditions
-70°C, aviod light
Package Size
100ug*1
Product Datasheet
Https://www.acrobiosystems.com/static/main/products/pdf/ds/CL2-HF218.pdf
Species
Human
Curated Selection
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