Mambalgin-2
Product Specifications
UNSPSC Description
Mambalgin-2 (Mamb-2) is an acid-sensitive ion channels (ASICs) inhibitor and a venom peptide. Mambalgin-2 can be obtained from the venom of the African black mamba. Mambalgin-2 can be used in the study of pain and neurological diseases[1].
Target Antigen
Sodium Channel
Type
Peptides
Related Pathways
Membrane Transporter/Ion Channel
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/mambalgin-2.html
Solubility
10 mM in DMSO
Smiles
O=C(C(N)CC(C)C)NC(C(N[C@H](C(NC(C(N[C@H](C(NC(C(NCC(NC(C(NC(C(N[C@H](C(N[C@@H](C(N[C@@H](C(N[C@H](C(NC(C(NC(C(NC(C(NC(C(N[C@H]1CC2=CC=CC=C2)=O)CCCCN)=O)CCSC)=O)CC(O)=O)=O)CCCNC(N)=N)=O)CC3=CNC=N3)=O)CS)=O)[C@H](C)O)=O)C(C)C)=O)C(C)C)=O)CCCCN)=O)=O)CC4=CNC=N4)=O)CCC(N)=O)=O)CC5=CC=CC=C5)=O)CSSCC(NC1=O)C(NC(C(NC(C(NC(C(NC(C(NCC(NC(C(N6[C@H](C(NC(C(NC(C(NC(C(NC(C(NC(C(NC(C(NC(C(NC(C(NC(C(NCC(NC(C(NC(C(NC(C(NC(C(NC(C(NC(C(NC(C(N[C@@H](C(NC(C(NC(C(NC(C(NC7CCCCN)=O)CC(N)=O)=O)CC(N)=O)=O)CCC(O)=O)=O)C(C)O)=O)CCC(O)=O)=O)CO)=O)CSSCC(NC7=O)C(NC(C(NC(C(NC(C(NC(C(NC8CCCNC(N)=N)=O)CC(O)=O)=O)C(C)O)=O)CO)=O)CSSCC(NC8=O)C(NC(C(NC(C(O)=O)CCCCN)=O)CC(N)=O)=O)=O)=O)CO)=O)CO)=O)CO)=O)CS)=O)=O)CCC(N)=O)=O)CC(C)C)=O)C(CC)C)=O)CC(C)C)=O)CCCCN)=O)CC(C)C)=O)CC(N)=O)=O)CCCNC(N)=N)=O)CC9=CC=CC=C9)=O)CCC6)=O)CCSC)=O)=O)C(C)O)=O)CC(N)=O)=O)CC%10=CNC=N%10)=O)CC%11=CC=C(O)C=C%11)=O)=O)CCCCN
Molecular Weight
6540.50
References & Citations
[1]Salinas M, et al. Binding site and inhibitory mechanism of the mambalgin-2 pain-relieving peptide on acid-sensing ion channel 1a. J Biol Chem. 2014 May 9;289(19):13363-73.
Shipping Conditions
Room temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-P5863/Mambalgin-2-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-P5863/
Clinical Information
No Development Reported
Curated Selection
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