PreQ1 (dihydrochloride)
PreQ1 dihydrochloride is a modified, guanine-derived nucleobase and a precursor of Queuine biosynthesis. preQ1 dihydrochloride binds to the aptamer of PreQ1 riboswitch with high affinity[1].
Product Specifications
CAS Number
86694-45-3
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Nucleoside Antimetabolite/Analog
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage
Applications
Metabolism-protein/nucleotide metabolism
Field of Research
Metabolic Disease
Assay Protocol
https://www.medchemexpress.com/preq1-dihydrochloride.html
Purity
98.88
Solubility
DMSO : 125 mg/mL (ultrasonic) |H2O : 14.29 mg/mL (ultrasonic; warming; heat to 60°C)
Smiles
O=C1C2=C(NC=C2CN)N=C(N)N1.[H]Cl.[H]Cl
Molecular Formula
C7H11Cl2N5O
Molecular Weight
252.10
Precautions
H302, H315, H319, H335
References & Citations
[1]Connelly CM, et al. Synthetic ligands for PreQ1 riboswitches provide structural and mechanistic insights into targeting RNA tertiary structure. Nat Commun. 2019 Apr 2;10 (1) :1501.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture and light)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Frequently Asked Questions
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