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PreQ1 (dihydrochloride)

PreQ1 dihydrochloride is a modified, guanine-derived nucleobase and a precursor of Queuine (HY-N10574) biosynthesis. preQ1 dihydrochloride binds to the aptamer of PreQ1 riboswitch with high affinity[1].

Product Specifications

CAS Number

[86694-45-3]

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Nucleoside Antimetabolite/Analog

Type

Reference compound

Related Pathways

Cell Cycle/DNA Damage

Applications

Metabolism-protein/nucleotide metabolism

Field of Research

Metabolic Disease

Assay Protocol

https://www.medchemexpress.com/preq1-dihydrochloride.html

Purity

98.88

Solubility

DMSO : 125 mg/mL (ultrasonic) |H2O : 14.29 mg/mL (ultrasonic; warming; heat to 60°C)

Smiles

O=C1C2=C(NC=C2CN)N=C(N)N1.[H]Cl.[H]Cl

Molecular Formula

C7H11Cl2N5O

Molecular Weight

252.10

Precautions

H302, H315, H319, H335

References & Citations

[1]Connelly CM, et al. Synthetic ligands for PreQ1 riboswitches provide structural and mechanistic insights into targeting RNA tertiary structure. Nat Commun. 2019 Apr 2;10 (1) :1501.

Shipping Conditions

Room Temperature

Storage Conditions

4°C (Powder, sealed storage, away from moisture and light)

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Available Sizes

Curated Selection

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